生物共轭聚己内酯膜：一种新型伤口敷料。
Bio-conjugated polycaprolactone membranes: a novel wound dressing.
作者信息
Cai Elijah Zhengyang, Teo Erin Yiling, Jing Lim, Koh Yun Pei, Qian Tan Si, Wen Feng, Lee James Wai Kit, Hing Eileen Chor Hoong, Yap Yan Lin, Lee Hanjing, Lee Chuen Neng, Teoh Swee-Hin, Lim Jane, Lim Thiam Chye
机构信息
Department of Surgery, National University Health System, Singapore.
Department of Reproductive Medicine, KK Women's and Children Hospital, Singapore.
出版信息
Arch Plast Surg. 2014 Nov;41(6):638-46. doi: 10.5999/aps.2014.41.6.638. Epub 2014 Nov 3.
BACKGROUND
The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing.
METHODS
16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration.
RESULTS
Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm(2), 4.90 cm(2), 3.12 cm(2), 1.84 cm(2); Mepitel (n=6): 10.29 cm(2), 5.53 cm(2), 3.63 cm(2), 2.02 cm(2); at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups.
CONCLUSIONS
BPM is comparable to Mepitel as a safe and efficacious wound dressing.
背景
聚己内酯和透明质酸的组合为伤口愈合创造了理想的环境。透明质酸可维持伤口湿润环境并加速肉芽组织向内生长。聚己内酯具有出色的机械强度，可限制炎症反应且具有生物相容性。本研究评估了生物共轭聚己内酯膜（BPM）作为伤口敷料的安全性和有效性。
方法
对16只新西兰白兔进行镇静并给予局部麻醉。在每只兔子背部最低肋骨与骨盆骨之间制造两个3.0×3.0 cm的全层伤口。伤口分别用BPM（n = 12）或Mepitel（n = 12）（对照，一种聚酰胺 - 硅伤口敷料）进行包扎。在术后第7、14、21和28天对伤口进行宏观评估，观察肉芽组织、再上皮化、感染情况及伤口大小，并进行组织学评估以观察表皮和真皮再生情况。
结果
两组的肉芽组织生长和再上皮化程度相当。未观察到感染迹象。两组之间伤口大小无显著差异（P>0.05）。术后第7、14、21和28天，BPM组（n = 6）伤口面积分别为8.33 cm²、4.90 cm²、3.12 cm²、1.84 cm²；Mepitel组（n = 6）分别为10.29 cm²、5.53 cm²、3.63 cm²、2.02 cm²。两组的表皮和真皮再生程度相当。
结论
BPM作为一种安全有效的伤口敷料与Mepitel相当。
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