激光扫描激光二极管光声显微镜系统。
Laser scanning laser diode photoacoustic microscopy system.
作者信息
Erfanzadeh Mohsen, Kumavor Patrick D, Zhu Quing
机构信息
Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
出版信息
Photoacoustics. 2017 Nov 13;9:1-9. doi: 10.1016/j.pacs.2017.10.001. eCollection 2018 Mar.
The development of low-cost and fast photoacoustic microscopy systems enhances the clinical applicability of photoacoustic imaging systems. To this end, we present a laser scanning laser diode-based photoacoustic microscopy system. In this system, a 905 nm, 325 W maximum output peak power pulsed laser diode with 50 ns pulsewidth is utilized as the light source. A combination of aspheric and cylindrical lenses is used for collimation of the laser diode beam. Two galvanometer scanning mirrors steer the beam across a focusing aspheric lens. The lateral resolution of the system was measured to be ∼21 μm using edge spread function estimation. No averaging was performed during data acquisition. The imaging speed is ∼370 A-lines per second. Photoacoustic microscopy images of human hairs, mouse ear, and porcine ovary are presented to demonstrate the feasibility and potentials of the proposed system.
低成本且快速的光声显微镜系统的发展提高了光声成像系统的临床适用性。为此，我们展示了一种基于激光扫描激光二极管的光声显微镜系统。在该系统中，一个905 nm、最大输出峰值功率为325 W、脉冲宽度为50 ns的脉冲激光二极管被用作光源。非球面透镜和柱面透镜的组合用于准直激光二极管光束。两个振镜扫描镜引导光束穿过一个聚焦非球面透镜。使用边缘扩展函数估计测量该系统的横向分辨率约为21μm。在数据采集期间未进行平均处理。成像速度约为每秒370条A线。展示了人发、小鼠耳朵和猪卵巢的光声显微镜图像，以证明所提出系统的可行性和潜力。
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