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Rheumatoid arthritis: Seronegative and seropositive RA: alike but different?

作者信息

Ajeganova Sofia, Huizinga Tom W J

机构信息

Rheumatology Unit R92, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm 14186, Sweden.

Department of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, Netherlands.

出版信息

Nat Rev Rheumatol. 2015 Jan;11(1):8-9. doi: 10.1038/nrrheum.2014.194. Epub 2014 Nov 18.

DOI:10.1038/nrrheum.2014.194
PMID:25403158
Abstract
摘要

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本文引用的文献

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Prognosis of seronegative patients in a large prospective cohort of patients with early inflammatory arthritis.早期炎症性关节炎患者大型前瞻性队列中血清学阴性患者的预后
J Rheumatol. 2014 Dec;41(12):2361-9. doi: 10.3899/jrheum.140082. Epub 2014 Oct 1.
2
ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial.抗环瓜氨酸肽抗体阳性和阴性的类风湿性关节炎在联合使用改善病情抗风湿药和皮质类固醇方面的需求存在差异：一项随机对照试验的二次分析
Arthritis Res Ther. 2014 Jan 16;16(1):R13. doi: 10.1186/ar4439.
3
Should we redefine treatment targets in rheumatoid arthritis? Low disease activity is sufficiently strict for patients who are anticitrullinated protein antibody-negative.
克隆性造血与不同的类风湿关节炎表型相关。
Sci Adv. 2025 May 2;11(18):eadt9846. doi: 10.1126/sciadv.adt9846. Epub 2025 Apr 30.
4
Causal Relationships Between Environmental Exposures, Iron Metabolism, Hematuria Markers, and Rheumatoid Arthritis: An Investigation Using Mendelian Randomization.环境暴露、铁代谢、血尿标志物与类风湿关节炎之间的因果关系：一项孟德尔随机化研究
Biomedicines. 2025 Feb 19;13(2):513. doi: 10.3390/biomedicines13020513.
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Rheumatoid arthritis unmasked: the power of B cell depletion therapy.类风湿关节炎真相大白：B细胞耗竭疗法的作用
Mol Biol Rep. 2025 Feb 20;52(1):254. doi: 10.1007/s11033-025-10366-w.
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The role of Anti-PAD4, Anti-CarP, and Anti-RA33 antibodies combined with RF and ACPA in predicting abatacept response in rheumatoid arthritis.抗瓜氨酸化蛋白抗体4（Anti-PAD4）、抗瓜氨酸化肽（Anti-CarP）和抗RA33抗体联合类风湿因子（RF）及抗环瓜氨酸肽抗体（ACPA）在预测类风湿关节炎患者对阿巴西普反应中的作用
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Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis.在免疫介导的难治性关节炎中组织归巢 CD4+和 CD8+T 细胞克隆的单细胞特征。
Mol Med. 2024 Apr 9;30(1):48. doi: 10.1186/s10020-024-00802-1.
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The Impact of Microbiota-Immunity-Hormone Interactions on Autoimmune Diseases and Infection.微生物群-免疫-激素相互作用对自身免疫性疾病和感染的影响
Biomedicines. 2024 Mar 8;12(3):616. doi: 10.3390/biomedicines12030616.
我们是否应该重新定义类风湿关节炎的治疗目标？对于抗瓜氨酸化蛋白抗体阴性的患者，低疾病活动度已经足够严格。
J Rheumatol. 2013 Aug;40(8):1268-74. doi: 10.3899/jrheum.121438. Epub 2013 Jun 1.
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Autoimmunity in rheumatoid arthritis: different antigens--common principles.类风湿关节炎中的自身免疫：不同的抗原——共同的原则。
Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii132-6. doi: 10.1136/annrheumdis-2012-202349. Epub 2012 Dec 19.
5
Remission induction therapy with methotrexate and prednisone in patients with early rheumatoid and undifferentiated arthritis (the IMPROVED study).甲氨蝶呤和泼尼松诱导缓解治疗早期类风湿关节炎和未分化关节炎患者（IMPROVED 研究）。
Ann Rheum Dis. 2012 Sep;71(9):1472-7. doi: 10.1136/annrheumdis-2011-200736. Epub 2012 Mar 8.
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Sustained drug-free remission in rheumatoid arthritis after DAS-driven or non-DAS-driven therapy: a comparison of two cohort studies.基于 DAS 或非 DAS 治疗的类风湿关节炎持续药物缓解：两项队列研究比较。
Rheumatology (Oxford). 2012 Jun;51(6):1120-8. doi: 10.1093/rheumatology/ker516. Epub 2012 Feb 15.
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The influence of ACPA status and characteristics on the course of RA.ACPA 状态和特征对 RA 病程的影响。
Nat Rev Rheumatol. 2012 Jan 31;8(3):144-52. doi: 10.1038/nrrheum.2011.204.
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The association of treatment response and joint damage with ACPA-status in recent-onset RA: a subanalysis of the 8-year follow-up of the BeSt study.早期发病 RA 中治疗应答和关节损伤与 ACPA 状态的相关性：BeSt 研究 8 年随访的亚分析。
Ann Rheum Dis. 2012 Feb;71(2):245-8. doi: 10.1136/annrheumdis-2011-200379. Epub 2011 Nov 21.
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Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?抗环瓜氨酸肽抗体阴性类风湿关节炎能否进一步分为临床亚表型？
Arthritis Res Ther. 2011;13(5):R180. doi: 10.1186/ar3505. Epub 2011 Oct 27.
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Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage.自身抗体识别氨基甲酰化蛋白存在于类风湿关节炎患者的血清中，并可预测关节损伤。
Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17372-7. doi: 10.1073/pnas.1114465108. Epub 2011 Oct 10.