Win Nwet Nwet, Kyaw May Mon, Ngwe Hla, Ito Takuya, Asakawa Yoshinori, Okamoto Yasuko, Tanaka Masami, Abe Ikuro, Morita Hiroyuki
Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
Department of Chemistry, University of Yangon, Yangon, 11041, Myanmar.
Chem Biodivers. 2019 Apr;16(4):e1800657. doi: 10.1002/cbdv.201800657. Epub 2019 Mar 19.
A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4',7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).
从缅甸下缅甸采集的野生型圆叶姜根茎的氯仿可溶粗提物中分离出一种新的二降蒈烷二萜类化合物，西克福钦那 A（1），以及四种已知化合物，豆甾醇（2）、4',7-二甲基山奈酚（3）、加兰醛 A（4）和 B（5）。通过多种光谱方法结合鉴定了这些化合物的化学结构。二萜类化合物 1、4 和 5 的存在证明了野生型圆叶姜的结构多样性。在分离出的化合物中，化合物 4 和 5 对一小部分人类癌细胞系表现出显著的抗增殖活性，包括肺癌（LK-2、A549）、胃癌（ECC4）、乳腺癌（MCF7）、宫颈癌（HeLa）和前列腺癌（DU145）。
