Bruhn H, Frahm J, Gyngell M L, Merboldt K D, Hänicke W, Sauter R
Max-Planck-Institut für biophysikalische Chemie, Göttingen, Federal Republic of Germany.
Magn Reson Med. 1989 Jan;9(1):126-31. doi: 10.1002/mrm.1910090115.
Localized proton NMR spectroscopy at 1.5 T using stimulated echoes has been applied to study metabolic alterations in the postischemic phase of patients with acute cerebral infarction. A complete depletion of N-acetyl aspartate in the area of infarction has been observed in a patient studied 4 days after stroke. This finding was paralleled by a dramatic increase in the concentration of lactic acid to about 16 mM within the lesion, indicating continued anaerobic glycolysis. The diluting effect of the edema has been estimated to reduce average metabolite concentrations by about a factor of 3.
使用受激回波的1.5T局部质子核磁共振波谱已被应用于研究急性脑梗死患者缺血后阶段的代谢改变。在一名中风后4天接受研究的患者中，观察到梗死区域的N-乙酰天门冬氨酸完全耗尽。这一发现与病变内乳酸浓度急剧增加至约16 mM相平行，表明无氧糖酵解仍在继续。据估计，水肿的稀释作用可使代谢物平均浓度降低约3倍。
