Tang Jinsong, Morgan Hannah L, Liao Yanhui, Corlett Philip R, Wang Dong, Li Hong, Tang Yanqing, Chen Jindong, Liu Tieqiao, Hao Wei, Fletcher Paul C, Chen Xiaogang
Institute of Mental Health, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People's Republic of China.
Psychopharmacology (Berl). 2015 May;232(9):1515-26. doi: 10.1007/s00213-014-3782-0. Epub 2014 Nov 19.
Subanaesthetic ketamine infusion in healthy volunteers induces experiences redolent of early psychosis, including changes in the experience of one's own body. It is not clear, however, whether repeated self-administration of ketamine has a sustained effect on body representation that is comparable to that found during acute administration.
We sought to establish whether chronic ketamine use resulted in disturbances to sense of body ownership.
Following on from our work on the effects of acute ketamine infusion, we used the rubber hand illusion (RHI) to experimentally manipulate the sense of body ownership in chronic ketamine users, compared to healthy controls.
Chronic ketamine users experienced the RHI more strongly and reported more body-image aberrations, even though they had not recently taken the drug.
These findings suggest that the chronic ketamine model for psychosis models more long-lasting changes in sense of ownership, perhaps more akin to schizophrenia.
在健康志愿者中输注亚麻醉剂量的氯胺酮会引发类似早期精神病的体验，包括自身身体体验的变化。然而，尚不清楚重复自我给药氯胺酮是否会对身体表征产生持续影响，这种影响是否与急性给药时观察到的相当。
我们试图确定长期使用氯胺酮是否会导致身体自我认知障碍。
基于我们对急性输注氯胺酮效果的研究，我们使用橡皮手错觉（RHI）实验性地操纵长期氯胺酮使用者的身体自我认知，并与健康对照组进行比较。
长期氯胺酮使用者对橡皮手错觉的体验更强烈，且报告了更多的身体意象畸变，即便他们近期未使用过该药物。
这些发现表明，用于精神病研究的长期氯胺酮模型模拟了身体自我认知方面更持久的变化，可能更类似于精神分裂症。
