Song Qingkun, Christiani David C, Ren Jun
Beijing Key Laboratory of Cancer Therapeutic Vaccine, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Tie Yi Road 10, Haidian District, Beijing 100038, China.
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
Int J Environ Res Public Health. 2014 Nov 14;11(11):11822-32. doi: 10.3390/ijerph111111822.
This study aimed to investigate the quantitative effects of outdoor air pollution, represented by 10 µg/m(3) increment of PM10, on chronic obstructive pulmonary disease in China, United States and European Union through systematic review and meta-analysis.
Publications in English and Chinese from PubMed and EMBASE were selected. The Cochrane Review Handbook of Generic Inverse Variance was used to synthesize the pooled effects on incidence, prevalence, mortality and hospital admission.
Outdoor air pollution contributed to higher incidence and prevalence of COPD. Short-term exposure was associated with COPD mortality increased by 6%, 1% and 1% in the European Union, the United States and China, respectively (p < 0.05). Chronic PM exposure produced a 10% increase in mortality. In a short-term exposure to 10 µg/m(3) PM10 increment COPD mortality was elevated by 1% in China (p < 0.05) and hospital admission enrollment was increased by 1% in China, 2% in United States and 1% in European Union (p < 0.05).
Outdoor air pollution contributes to the increasing burdens of COPD.10 µg/m(3) increase of PM10 produced significant condition of COPD death and exacerbation in China, United States and European Union. Controlling air pollution will have substantial benefit to COPD morbidity and mortality.
本研究旨在通过系统评价和荟萃分析，调查以PM10每增加10微克/立方米为代表的室外空气污染对中国、美国和欧盟慢性阻塞性肺疾病的定量影响。
从PubMed和EMBASE中筛选英文和中文出版物。采用Cochrane系统评价手册中的通用逆方差法综合分析空气污染对发病率、患病率、死亡率和住院率的合并效应。
室外空气污染导致慢性阻塞性肺疾病的发病率和患病率升高。短期暴露与慢性阻塞性肺疾病死亡率增加有关，在欧盟、美国和中国，短期暴露分别使慢性阻塞性肺疾病死亡率增加6%、1%和1%（p<0.05）。长期暴露于可吸入颗粒物使死亡率增加10%。在中国，短期暴露于PM10每增加10微克/立方米，慢性阻塞性肺疾病死亡率升高1%（p<0.05），住院率在中国增加1%，在美国增加2%，在欧盟增加1%（p<0.05）。
室外空气污染导致慢性阻塞性肺疾病负担加重。在中国、美国和欧盟，PM10每增加10微克/立方米会导致慢性阻塞性肺疾病死亡和病情加重的显著增加。控制空气污染将对慢性阻塞性肺疾病的发病率和死亡率产生重大益处。
