Department of Chemistry, Indiana University , 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.
Department of Chemistry, University of California, Davis , 1 Shields Avenue, Davis, California 95616, United States.
Org Lett. 2017 Jul 21;19(14):3703-3706. doi: 10.1021/acs.orglett.7b01420. Epub 2017 Jul 7.
Intramolecular chirality transfer [2 + 2] cycloaddition of enantiomerically enriched allenoates and alkenes is presented. The use of a chiral catalyst was found to be critical to achieve high levels of diastereoselectivity compared to use of an achiral catalyst. The method developed leads to highly substituted cyclobutanes that would be difficult to prepare by alternative methods.
本文报道了通过对映体富集的丙二烯酸酯和烯烃的分子内手性转移[2 + 2]环加成反应。与使用非手性催化剂相比,使用手性催化剂对于实现高水平的非对映选择性至关重要。所开发的方法得到了高度取代的环丁烷,这些环丁烷通过其他方法难以制备。