超低强度近红外光通过上转换纳米颗粒诱导药物递送。
Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles.
作者信息
He Shuqing, Krippes Kristina, Ritz Sandra, Chen Zhijun, Best Andreas, Butt Hans-Jürgen, Mailänder Volker, Wu Si
机构信息
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
出版信息
Chem Commun (Camb). 2015 Jan 7;51(2):431-4. doi: 10.1039/c4cc07489k. Epub 2014 Nov 19.
PMID:25407146
Abstract
Mesoporous silica coated upconverting nanoparticles are loaded with the anticancer drug doxorubicin and grafted with ruthenium complexes as photoactive molecular valves. Drug release was triggered by 974 nm light with 0.35 W cm(-2). Such low light intensity minimized overheating problems and prevented photodamage to biological samples.
摘要
介孔二氧化硅包覆的上转换纳米颗粒负载了抗癌药物阿霉素，并接枝了钌配合物作为光活性分子阀门。药物释放由强度为0.35 W cm(-2)的974 nm光触发。如此低的光强度将过热问题降至最低，并防止了对生物样品的光损伤。
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