Czeglédy J, Gergely L, Batár I
Institute of Microbiology, University Medical School, Debrecen, Hungary.
Arch Gynecol Obstet. 1989;244(2):87-9. doi: 10.1007/BF00931378.
Cervical cells were screened for human papillomavirus (HPV) infections by in situ filter hybridization in 108 patients wearing intrauterine contraceptive devices. The cells were tested for the presence of HPV 6, 11, 16, 18 DNA. In 86 cases (79.6%) no reactions were obtained with 32P-labeled HPV DNA probes. 22 smears (20.3%) were positive for HPV: type 6 and 11 sequences were demonstrated in 17 cases (3 of them carried both). 4 smears hybridized with the probe for oncogenic HPV 16 and one with that for oncogenic type 18. All these five patients had normal smears and no abnormality on colposcopy.
通过原位滤膜杂交法对108例佩戴宫内节育器患者的宫颈细胞进行人乳头瘤病毒（HPV）感染筛查。检测细胞中HPV 6、11、16、18型DNA的存在情况。86例（79.6%）与32P标记的HPV DNA探针无反应。22份涂片（20.3%）HPV检测呈阳性：17例检测到6型和11型序列（其中3例同时携带两种类型）。4份涂片与致癌性HPV 16型探针杂交，1份与致癌性18型探针杂交。这5例患者的涂片均正常，阴道镜检查无异常。
