Gissmann L, Wolnik L, Ikenberg H, Koldovsky U, Schnürch H G, zur Hausen H
Proc Natl Acad Sci U S A. 1983 Jan;80(2):560-3. doi: 10.1073/pnas.80.2.560.
Human genital tumors as well as recurrent laryngeal papillomas were analyzed for the presence of human papillomavirus (HPV) 6 and HPV 11 sequences. HPV 11 DNA was found in 7 of 14 laryngeal papillomas; in the 7 other tumors no HPV DNA was demonstrated. HPV 11 DNA was also found in all five atypical condylomata of the cervix included in this study. Condylomata acuminata mainly contained HPV 6 DNA. From 63 biopsy specimens, 41 clearly harbored HPV 6 DNA and 13 harbored HPV 11 DNA. In three tumors accurate typing was impossible, and in six additional ones neither HPV 6 nor HPV 11 DNA could be demonstrated. The data support a genital origin of laryngeal papillomavirus infections. In 4 of 24 malignant tumors, HPV 11 DNA or related sequences were demonstrated; 2 of the 4 were biopsy specimens from invasive cancer, and the other 2 originated from carcinomata in situ. A possible role of this or related papillomavirus types in the induction of malignant genital tumors remains to be elucidated.
对人类生殖器肿瘤以及复发性喉乳头状瘤进行分析，以检测人乳头瘤病毒（HPV）6型和HPV 11型序列的存在情况。在14例喉乳头状瘤中有7例发现了HPV 11 DNA；在其他7例肿瘤中未检测到HPV DNA。在本研究纳入的所有5例宫颈非典型湿疣中也发现了HPV 11 DNA。尖锐湿疣主要含有HPV 6 DNA。在63份活检标本中，41份明确含有HPV 6 DNA，13份含有HPV 11 DNA。在3例肿瘤中无法进行准确分型，另外6例既未检测到HPV 6 DNA也未检测到HPV 11 DNA。这些数据支持喉乳头状瘤病毒感染起源于生殖器。在24例恶性肿瘤中有4例检测到HPV 11 DNA或相关序列；其中2例是浸润性癌的活检标本，另外2例起源于原位癌。这种或相关乳头瘤病毒类型在恶性生殖器肿瘤诱发中的可能作用仍有待阐明。
