Geamănu Pancă A, Popa-Cherecheanu A, Marinescu B, Geamănu C D, Voinea L M
Ophthalmology Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest.
"Victor Babeș"' National Institute of Pathology, Bucharest.
J Med Life. 2014 Sep 15;7(3):322-6. Epub 2014 Sep 25.
Hydroxychloroquine sulfate (HCQ, Plaquenil) is an analogue of chloroquine (CQ), an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Because it presents potential secondary effects including irreversible maculopathy, knowledge of incidence, risk factors, drug toxicity and protocol screening of the patients it represents important data for the ophthalmologists. Thus, it is imperative that rheumatologists, medical internists and ophthalmologists are aware of the toxicity from hydroxychloroquine they should also be careful to minimize its occurrence and effects.
硫酸羟氯喹（HCQ，商品名：羟氯喹）是氯喹（CQ）的类似物，一种抗疟药，用于治疗系统性红斑狼疮、类风湿性关节炎和其他自身免疫性疾病。其使用与严重的视网膜毒性有关，需要停药。由于它存在包括不可逆黄斑病变在内的潜在副作用，了解其发病率、危险因素、药物毒性以及对患者的筛查方案，对眼科医生来说是重要的数据。因此，风湿科医生、内科实习医生和眼科医生必须意识到羟氯喹的毒性，他们也应小心尽量减少其发生和影响。
