Salentijn Gert I J, Permentier Hjalmar P, Verpoorte Elisabeth
Pharmaceutical Analysis, Groningen Research Institute of Pharmacy, University of Groningen , P.O. Box 196, 9700 AD Groningen, The Netherlands.
Anal Chem. 2014 Dec 2;86(23):11657-65. doi: 10.1021/ac502785j. Epub 2014 Nov 19.
We report the development of a 3D-printed cartridge for paper spray ionization (PSI) that can be used almost immediately after solvent introduction in a dedicated reservoir and allows prolonged spray generation from a paper tip. The fast wetting feature described in this work is based on capillary action through paper and movement of fluid between paper and the cartridge material (polylactic acid, PLA). The influence of solvent composition, PLA conditioning of the cartridge with isopropanol, and solvent volume introduced into the reservoir have been investigated with relation to wetting time and the amount of solvent consumed for wetting. Spray has been demonstrated with this cartridge for tens of minutes, without any external pumping. It is shown that fast wetting and spray generation can easily be achieved using a number of solvent mixtures commonly used for PSI. The PSI cartridge was applied to the analysis of lidocaine from a paper tip using different solvent mixtures, and to the analysis of lidocaine from a serum sample. Finally, a demonstration of online paper chromatography-mass spectrometry is given.
我们报告了一种用于纸喷雾电离（PSI）的3D打印盒的研发情况，该盒在专用储液器中引入溶剂后几乎可立即使用，并能使纸尖端产生长时间的喷雾。本工作中描述的快速润湿特性基于通过纸张的毛细作用以及流体在纸张和盒材料（聚乳酸，PLA）之间的移动。研究了溶剂组成、用异丙醇对盒进行PLA预处理以及引入储液器中的溶剂量对润湿时间和润湿所消耗溶剂量的影响。使用该盒在无任何外部泵送的情况下已实现了数十分钟的喷雾。结果表明，使用多种常用于PSI的溶剂混合物能够轻松实现快速润湿和喷雾产生。该PSI盒被应用于使用不同溶剂混合物从纸尖端分析利多卡因，以及从血清样品中分析利多卡因。最后，给出了在线纸色谱 - 质谱分析的演示。
