Sanyelbhaa Hossam, Sanyelbhaa Ahmed
Audiology Unit, ENT Department, Menoufiya University, Shibin Al Kawm, Al Minufiyah, Egypt.
Internal Medicine Department, Suez Canal University, Ismaileya, Egypt.
Eur Arch Otorhinolaryngol. 2015 Nov;272(11):3233-9. doi: 10.1007/s00405-014-3395-6. Epub 2014 Nov 20.
Otolith function in subjects with vitamin D deficiency/insufficiency is investigated through vestibular-evoked myogenic potentials (VEMP) and subjective visual vertical (SVV) testing. The study group included 62 patients with vitamin D deficiency/insufficiency (30 females, 32 males), with age range 24-56 years (40.6 ± 9.1). The control group included 44 healthy volunteers of similar age and gender distribution. The entire study group had: (1) serum level of 25-hydroxyvitamin D <30 ng/ml; (2) normal bone mineral density as indicated by dual-energy X-ray absorptiometry with T-score >-1; (3) normal middle ear function; (4) Age is ≤60 years. All subjects enrolled in the current study underwent audiovestibular evaluation consisting of pure-tone audiometry, immittancemetry, cervical VEMP (cVEMP), ocular VEMP (oVEMP), and SSV. The entire control group had normal cVEMP, two subjects had abnormal oVEMP. Thirty-three subjects (53%) in the study group had abnormal oVEMP and 31 subjects (50%) had abnormal cVEMP. Forty-one (66%) had abnormal VEMP when abnormal VEMP was considered as either abnormal oVEMP or cVEMP. The entire control and study groups had normal SSV test results. Vitamin D deficiency may be associated with development of otolith dysfunction affecting both the utricle and saccule. This was suggested by the high prevalence of abnormal ocular vestibular-evoked myogenic potentials (oVEMP) and cervical vestibular-evoked myogenic potentials (cVEMP) in the study group.
通过前庭诱发肌源性电位（VEMP）和主观视觉垂直线（SVV）测试，对维生素D缺乏/不足受试者的耳石功能进行了研究。研究组包括62例维生素D缺乏/不足患者（30例女性，32例男性），年龄范围为24 - 56岁（40.6±9.1）。对照组包括44名年龄和性别分布相似的健康志愿者。整个研究组具有以下特征：（1）血清25 - 羟维生素D水平<30 ng/ml；（2）双能X线吸收法显示骨密度正常，T值>-1；（3）中耳功能正常；（4）年龄≤60岁。本研究纳入的所有受试者均接受了包括纯音听力测定、声导抗测试、颈肌前庭诱发肌源性电位（cVEMP）、眼肌前庭诱发肌源性电位（oVEMP）和主观视觉垂直线测试在内的听前庭评估。整个对照组的cVEMP正常，两名受试者的oVEMP异常。研究组中有33名受试者（53%）的oVEMP异常，31名受试者（50%）的cVEMP异常。当将异常的VEMP视为异常的oVEMP或cVEMP时，41名（66%）受试者的VEMP异常。整个对照组和研究组的主观视觉垂直线测试结果均正常。维生素D缺乏可能与影响椭圆囊和球囊的耳石功能障碍的发生有关。研究组中眼肌前庭诱发肌源性电位（oVEMP）和颈肌前庭诱发肌源性电位（cVEMP）异常的高发生率表明了这一点。
