变应性炎症——本质上是稳态的。
Allergic inflammation--innately homeostatic.
作者信息
Cheng Laurence E, Locksley Richard M
机构信息
Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143.
Department of Medicine, University of California, San Francisco, San Francisco, California 94143 Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California 94143 Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143.
出版信息
Cold Spring Harb Perspect Biol. 2014 Nov 20;7(3):a016352. doi: 10.1101/cshperspect.a016352.
Allergic inflammation is associated closely with parasite infection but also asthma and other common allergic diseases. Despite the engagement of similar immunologic pathways, parasitized individuals often show no outward manifestations of allergic disease. In this perspective, we present the thesis that allergic inflammatory responses play a primary role in regulating circadian and environmental inputs involved with tissue homeostasis and metabolic needs. Parasites feed into these pathways and thus engage allergic inflammation to sustain aspects of the parasitic life cycle. In response to parasite infection, an adaptive and regulated immune response is layered on the host effector response, but in the setting of allergy, the effector response remains unregulated, thus leading to the cardinal features of disease. Further understanding of the homeostatic pressures driving allergic inflammation holds promise to further our understanding of human health and the treatment of these common afflictions.
过敏性炎症不仅与寄生虫感染密切相关，还与哮喘和其他常见过敏性疾病相关。尽管涉及相似的免疫途径，但感染寄生虫的个体通常没有过敏性疾病的外在表现。从这个角度来看，我们提出这样一个论点，即过敏性炎症反应在调节与组织稳态和代谢需求相关的昼夜节律和环境输入方面起主要作用。寄生虫进入这些途径，从而引发过敏性炎症以维持寄生虫生命周期的各个方面。针对寄生虫感染，适应性和受调节的免疫反应叠加在宿主效应反应之上，但在过敏情况下，效应反应仍不受调节，从而导致疾病的主要特征。进一步了解驱动过敏性炎症的稳态压力有望加深我们对人类健康以及这些常见疾病治疗方法的理解。
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