用于蛋白质介导治疗与递送的纳米材料
NANOMATERIALS FOR PROTEIN MEDIATED THERAPY AND DELIVERY.
作者信息
Barry John N, Vertegel Alexey A
机构信息
Department of Bioengineering, Clemson University, 301 Rhodes Hall, Clemson, SC 29634, United States,
出版信息
Nano Life. 2013 Dec 27;3(4). doi: 10.1142/S1793984413430010.
Abstract
There has been a significant amount of research done on liposomes and nanoparticles as drug carriers for protein drugs. Proteins and enzymes have been used both as targeting moieties and for their therapeutic potential. High specificity and rapid reaction rates make proteins and enzymes excellent candidates for therapeutic treatment, but some limitations exist. Many of these limitations can be addressed by a well studied nanotechnology based delivery system. Such a system can provide a medium for delivery, stabilization of the drugs, and enable site specific accumulation of drugs. Nanomedicines such as these have great potential to revolutionize the pharmaceutical industry and improve healthcare worldwide.
摘要
关于脂质体和纳米颗粒作为蛋白质药物载体，已经开展了大量研究。蛋白质和酶既被用作靶向部分，也因其治疗潜力而被使用。高特异性和快速反应速率使蛋白质和酶成为治疗的理想候选物，但也存在一些局限性。基于纳米技术的递送系统经过充分研究，可以解决其中许多局限性。这样的系统可以提供递送介质、稳定药物，并实现药物的位点特异性积累。这类纳米药物具有巨大潜力，能够彻底改变制药行业并改善全球医疗保健状况。
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