白细胞介素6 - 174G/C基因多态性与骨折风险
IL6-174G/C polymorphism and fracture risk.
作者信息
Zhang Zhichang, He Nengbin, Zhang Tao
机构信息
Department of Orthopedics, The Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai 200233, China.
出版信息
Int J Clin Exp Med. 2014 Oct 15;7(10):3795-9. eCollection 2014.
Several studies have examined the associations of polymorphism in interleukin-6 (IL6) with fracture risk. However, the results were conflicting. Thus, a meta-analysis was conducted to determine the relationship between IL6-174C/G polymorphism and risk of fracture. Databases including PubMed, EMBASE, Wanfang were searched. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. Six studies were included in this meta-analysis. IL6-174C/G polymorphism was associated with a significantly increased risk of fracture (OR=1.32; 95% CI, 1.10-1.58; I(2) =11%; Figure 1). In the subgroup analysis according to gender, women (RR=1.26; 95% CI, 1.09-1.46; I(2) =0%) was significantly associated with risk of fracture. In the age subgroup analysis, old population (RR=1.27; 95% CI, 1.11-1.48; I(2) =0%) showed increased fracture risk. However, young population did show increased risk of fracture (RR=1.95; 95% CI, 0.70-5.47; I(2) =51%). Postmenopausal women also showed an increased fracture risks (RR=1.24; 95% CI, 1.08-1.44; I(2) =0%). This meta-analysis suggested that IL6-174C/G polymorphism contributed the development of fracture.
多项研究探讨了白细胞介素-6（IL6）基因多态性与骨折风险之间的关联。然而，研究结果相互矛盾。因此，进行了一项荟萃分析以确定IL6 - 174C/G基因多态性与骨折风险之间的关系。检索了包括PubMed、EMBASE、万方在内的数据库。使用随机效应模型估计汇总比值比（OR）和相应的95%置信区间（CI）。本荟萃分析纳入了六项研究。IL6 - 174C/G基因多态性与骨折风险显著增加相关（OR = 1.32；95% CI，1.10 - 1.58；I² = 11%；图1）。在按性别进行的亚组分析中，女性（RR = 1.26；95% CI，1.09 - 1.46；I² = 0%）与骨折风险显著相关。在年龄亚组分析中，老年人群（RR = 1.27；95% CI，1.11 - 1.48；I² = 0%）骨折风险增加。然而，年轻人群并未显示出骨折风险增加（RR = 1.95；95% CI，0.70 - 5.47；I² = 51%）。绝经后女性也显示出骨折风险增加（RR = 1.24；95% CI，1.08 - 1.44；I² = 0%）。这项荟萃分析表明，IL6 - 174C/G基因多态性促成了骨折的发生。
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