Jin X F, Wang D L, Zhou Y, Xiong H
Shandong University Hospital of Traditional Chinese Medicine, Jinan, China.
Department of Neurosurgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Genet Mol Res. 2015 Oct 26;14(4):13076-83. doi: 10.4238/2015.October.26.3.
Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase databases were retrieved. Pooled ORs with 95%CIs were calculated using fixed- or random-effect models. A total of seven case-control studies containing 2025 patients and 2174 controls were enrolled into this meta-analysis. In combined analysis, the results showed no significant association between the IL6 -174 G/C polymorphism and ischemic stroke risk in the overall population (GG vs CC: OR = 1.22, 95%CI = 0.50-3.01; TT vs TC: OR = 0.97, 95%CI = 0.81-1.15; dominant: OR = 0.98, 95%CI = 0.70-1.38; or recessive: OR = 1.24, 95%CI = 0.57-2.70) models. In the subgroup analysis by race, no significant associations between the -174 G/C polymorphism in the IL6 gene and ischemic stroke risk were found in Caucasians or Asians. No publication bias was found in the present study (all P > 0.05). Overall, the meta-analysis results suggested that the IL6 -174 G/C polymorphism was not associated with an increased risk of ischemic stroke. Further large and well-designed studies are needed to confirm this conclusion.
众多研究评估了白细胞介素-6（IL6）基因-174 G/C多态性与缺血性中风风险之间的关联。然而，结果并不一致。在本研究中，我们进行了一项荟萃分析，以评估IL6 -174 G/C多态性与缺血性中风的关联。检索了来自PubMed和Embase数据库的已发表文献。使用固定效应或随机效应模型计算合并的比值比（OR）及其95%置信区间（CI）。本荟萃分析共纳入了7项病例对照研究，包括2025例患者和2174例对照。在合并分析中，结果显示在总体人群中，IL6 -174 G/C多态性与缺血性中风风险之间无显著关联（GG与CC：OR = 1.22，95%CI = 0.50 - 3.01；TT与TC：OR = 0.97，95%CI = 0.81 - 1.15；显性模型：OR = 0.98，95%CI = 0.70 - 1.38；隐性模型：OR = 1.24，95%CI = 0.57 - 2.70）。在按种族进行的亚组分析中，未发现IL6基因-174 G/C多态性与白种人或亚洲人的缺血性中风风险之间存在显著关联。本研究未发现发表偏倚（所有P > 0.05）。总体而言，荟萃分析结果表明，IL6 -174 G/C多态性与缺血性中风风险增加无关。需要进一步开展大规模且设计良好的研究来证实这一结论。
