Wang Chao, Zhang Gang, Gu Mingyong, Zhou Zhenyu, Cao Xuecheng
Department of Orthopedic Injury, General Hospital of Jinan Military Area Jinan 250031, Shandong, China.
Int J Clin Exp Med. 2014 Dec 15;7(12):5097-103. eCollection 2014.
Several molecular epidemiological studies have been conducted to examine the association between low-density lipoprotein receptor-related proteins (LRP5) Ala1330Val polymorphism and fracture; however, the conclusions remained controversial. We therefore performed an extensive meta-analysis on 10 published studies with 184479 subjects. Electronic databases, including PubMed, Excerpta Medica Database (EMBASE), Cochrane, Elsevier Science Direct and China National Knowledge Infrastructure (CNKI) databases were searched. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. LRP5 Ala1330Val polymorphism was associated with a significantly increased risk of fracture (OR = 1.10; 95% CI, 1.06-1.14; I(2) = 29%). We also found that this polymorphism increased fracture risk in Caucasians. In the subgroup analysis according to gender, women was significantly associated with risk of fracture. In the subgroup analysis by type of fracture, LRP5 Ala1330Val polymorphism showed increased osteoporotic fracture risk. In conclusion, this meta-analysis suggested that an increased risk of fracture was associated with the LRP5 Ala1330Val polymorphism.
已有多项分子流行病学研究探讨低密度脂蛋白受体相关蛋白（LRP5）Ala1330Val多态性与骨折之间的关联；然而，结论仍存在争议。因此，我们对10项已发表的研究（涉及184479名受试者）进行了全面的荟萃分析。检索了包括PubMed、医学文摘数据库（EMBASE）、Cochrane、爱思唯尔科学Direct和中国知网（CNKI）数据库在内的电子数据库。使用随机效应模型估计汇总比值比（OR）和相应的95%置信区间（CI）。LRP5 Ala1330Val多态性与骨折风险显著增加相关（OR = 1.10；95%CI，1.06 - 1.14；I(2) = 29%）。我们还发现这种多态性增加了白种人的骨折风险。在按性别进行的亚组分析中，女性与骨折风险显著相关。在按骨折类型进行的亚组分析中，LRP5 Ala1330Val多态性显示骨质疏松性骨折风险增加。总之，这项荟萃分析表明，骨折风险增加与LRP5 Ala1330Val多态性相关。
