白细胞介素-6基因多态性对骨折风险的影响。
Effect of interleukin-6 polymorphism on fracture risk.
作者信息
Wang Chuangli, Ge Jianfei, Ni Shanjun
机构信息
Department of Othopedic, The Fist People's Hospital of Zhangjiagang Zhangjiagang 215600, Jiang Su, China.
出版信息
Int J Clin Exp Med. 2015 Jun 15;8(6):9599-602. eCollection 2015.
BACKGROUND
Interleukin-6 (IL6) -174C/G polymorphism was suggested to be associated with fracture risk. However, the results were inconsistent. Thus, we did a meta-analysis.
METHODS
Reported studies were searched from online electronic databases of Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI). The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to assess the association between IL6 -174C/G polymorphism and fracture risk.
RESULTS
Six studies evaluated the association between IL6 -174C/G polymorphism and fracture risk. A significant association was found between IL6 -174C/G polymorphism and fracture risk (OR=1.25; 95% CI, 1.10-1.43; P=0.0008). In the subgroup analysis of gender, we found that women with IL6 -174C/G polymorphism had an increased fracture risk (OR=1.25; 95% CI, 1.07-1.46; P=0.005). In the subgroup analysis of type of fracture, we found that IL6 -174C/G polymorphism was significantly associated with wrist fracture (OR=1.25; 95% CI, 1.07-1.47; P=0.006) and osteoporotic fracture (OR=1.60; 95% CI, 1.12-2.28; P=0.009). However, no significant association was found between IL6 -174C/G polymorphism and hip fracture (OR=1.05; 95% CI, 0.89-1.24; P=0.53) and stress fracture (OR=1.25; 95% CI, 0.97-1.61; P=0.08).
CONCLUSION
This meta-analysis suggested that the IL6 -174C/G polymorphism was associated with wrist and osteoporotic fracture risk.
背景
白细胞介素-6（IL6）-174C/G多态性被认为与骨折风险相关。然而，结果并不一致。因此，我们进行了一项荟萃分析。
方法
从PubMed、EMBASE、中国知网（CNKI）等在线电子数据库中检索已发表的研究。计算比值比（OR）及相应的95%置信区间（CI），以评估IL6 -174C/G多态性与骨折风险之间的关联。
结果
六项研究评估了IL6 -174C/G多态性与骨折风险之间的关联。发现IL6 -174C/G多态性与骨折风险之间存在显著关联（OR=1.25；95%CI，1.10-1.43；P=0.0008）。在性别亚组分析中，我们发现具有IL6 -174C/G多态性的女性骨折风险增加（OR=1.25；95%CI，1.07-1.46；P=0.005）。在骨折类型亚组分析中，我们发现IL6 -174C/G多态性与腕部骨折（OR=1.25；95%CI，1.07-1.47；P=0.006）和骨质疏松性骨折（OR=1.60；95%CI，1.12-2.28；P=0.009）显著相关。然而，未发现IL6 -174C/G多态性与髋部骨折（OR=1.05；95%CI，0.89-1.24；P=0.53）和应力性骨折（OR=1.25；95%CI，0.97-1.61；P=0.08）之间存在显著关联。
结论
这项荟萃分析表明，IL6 -174C/G多态性与腕部和骨质疏松性骨折风险相关。
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