Goudra Basavana Gouda, Singh Preet Mohinder
Department of Clinical Anesthesiology and Critical Care, Perelman School of Medicine, 680 Dulles Building, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Department of Anesthesia, All India Institute of Medical Sciences, New Delhi, India.
Saudi J Anaesth. 2014 Oct;8(4):540-5. doi: 10.4103/1658-354X.140893.
Although propofol has been the backbone for sedation in gastrointestinal endoscopy, both anesthesiologists and endoscopists are faced with situations where an alternative is needed. Recent national shortages forced many physicians to explore these options. A midazolam and fentanyl combination is the mainstay in this area. However, there are other options. The aim of this review is to explore these options. The future would be, invariably, to move away from propofol. The reason is not in any way related to the drawbacks of propofol as a sedative. The mandate that requires an anesthesia provider to administer propofol has been a setback in many countries. New sedative drugs like Remimazolam might fill this void in the future. In the meantime, it is important to keep an open eye to the existing alternatives.
尽管丙泊酚一直是胃肠内镜检查中镇静的主要药物,但麻醉医生和内镜医生都面临着需要选择其他药物的情况。近期全国范围内的药物短缺迫使许多医生探索这些选择。咪达唑仑和芬太尼联合用药是这一领域的主要用药方式。然而,还有其他选择。本综述的目的是探索这些选择。未来必然会逐渐淘汰丙泊酚。原因与丙泊酚作为镇静剂的缺点毫无关系。在许多国家,要求麻醉人员使用丙泊酚的规定一直是个障碍。像瑞马唑仑这样的新型镇静药物可能会在未来填补这一空白。与此同时,关注现有的替代药物很重要。