一种在火鸡中引发淋巴增生性疾病的具有致癌性且能自主复制的病毒的分子克隆。
Molecular cloning of an oncogenic replication-competent virus that causes lymphoproliferative disease in turkeys.
作者信息
Gak E, Yaniv A, Chajut A, Ianconescu M, Tronick S R, Gazit A
机构信息
Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Israel.
出版信息
J Virol. 1989 Jun;63(6):2877-80. doi: 10.1128/JVI.63.6.2877-2880.1989.
The lymphoproliferative disease virus of turkeys was molecularly cloned, structurally mapped, and shown to represent a distinct class of retroviruses evolutionarily related to the avian leukemia-sarcoma virus group. The cloned provirus did not contain any known oncogene or other cellularly derived sequences and was established as a replication-competent oncogenic entity capable of inducing the disease in the absence of any associated transforming counterpart.
火鸡淋巴细胞增生性疾病病毒被进行了分子克隆、结构定位，并显示它代表了一类与禽白血病-肉瘤病毒组在进化上相关的独特逆转录病毒。克隆的前病毒不包含任何已知的癌基因或其他细胞来源的序列，并被确立为一个具有复制能力的致癌实体，能够在没有任何相关转化对应物的情况下诱发该疾病。
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