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一种在火鸡中引发淋巴增生性疾病的具有致癌性且能自主复制的病毒的分子克隆。

Molecular cloning of an oncogenic replication-competent virus that causes lymphoproliferative disease in turkeys.

作者信息

Gak E, Yaniv A, Chajut A, Ianconescu M, Tronick S R, Gazit A

机构信息

Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Israel.

出版信息

J Virol. 1989 Jun;63(6):2877-80. doi: 10.1128/JVI.63.6.2877-2880.1989.

DOI:10.1128/JVI.63.6.2877-2880.1989
PMID:2542599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250807/
Abstract

The lymphoproliferative disease virus of turkeys was molecularly cloned, structurally mapped, and shown to represent a distinct class of retroviruses evolutionarily related to the avian leukemia-sarcoma virus group. The cloned provirus did not contain any known oncogene or other cellularly derived sequences and was established as a replication-competent oncogenic entity capable of inducing the disease in the absence of any associated transforming counterpart.

摘要

火鸡淋巴细胞增生性疾病病毒被进行了分子克隆、结构定位，并显示它代表了一类与禽白血病-肉瘤病毒组在进化上相关的独特逆转录病毒。克隆的前病毒不包含任何已知的癌基因或其他细胞来源的序列，并被确立为一个具有复制能力的致癌实体，能够在没有任何相关转化对应物的情况下诱发该疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/250807/66b37d473f28/jvirol00073-0477-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/250807/d4255dec17cc/jvirol00073-0475-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/250807/1d89b581f6f7/jvirol00073-0476-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/250807/a4c1f76e1c65/jvirol00073-0477-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/250807/66b37d473f28/jvirol00073-0477-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/250807/d4255dec17cc/jvirol00073-0475-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/250807/1d89b581f6f7/jvirol00073-0476-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/250807/a4c1f76e1c65/jvirol00073-0477-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1811/250807/66b37d473f28/jvirol00073-0477-b.jpg

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本文引用的文献

1
Immunoglobulin gene expression in transformed lymphoid cells.转化淋巴细胞中的免疫球蛋白基因表达。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):825-9. doi: 10.1073/pnas.80.3.825.
2
New procedure for DNA transfection with polycation and dimethyl sulfoxide.使用聚阳离子和二甲基亚砜进行DNA转染的新方法。
Mol Cell Biol. 1984 Jun;4(6):1172-4. doi: 10.1128/mcb.4.6.1172-1174.1984.
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Nucleotide sequence analysis of the proviral genome of avian myelocytomatosis virus (MC29).禽骨髓细胞瘤病毒（MC29）前病毒基因组的核苷酸序列分析。
Proc Natl Acad Sci U S A. 1983 May;80(9):2500-4. doi: 10.1073/pnas.80.9.2500.
4
Genetic control of the organ specificity of lymphoproliferative disease virus (LPDV) of turkeys.火鸡淋巴细胞增生性疾病病毒（LPDV）器官特异性的遗传控制
Int J Cancer. 1983 Mar 15;31(3):351-6. doi: 10.1002/ijc.2910310316.
5
Organotropism of the lymphoproliferative disease virus (LPDV) of turkeys.火鸡淋巴增生性疾病病毒（LPDV）的器官嗜性
Int J Cancer. 1982 May 15;29(5):599-604. doi: 10.1002/ijc.2910290518.
6
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules.禽肉瘤病毒环状DNA分子的分子克隆与特性分析
J Virol. 1980 Oct;36(1):50-61. doi: 10.1128/JVI.36.1.50-61.1980.
7
Transfection of myeloid cell lines using polybrene/DMSO.使用聚凝胺/二甲基亚砜转染髓系细胞系。
Nucleic Acids Res. 1988 Mar 25;16(5):2352. doi: 10.1093/nar/16.5.2352.
8
Detection of specific sequences among DNA fragments separated by gel electrophoresis.在通过凝胶电泳分离的DNA片段中检测特定序列。
J Mol Biol. 1975 Nov 5;98(3):503-17. doi: 10.1016/s0022-2836(75)80083-0.
9
Molecular evidence for a type C retrovirus etiology of the lymphoproliferative disease of turkeys.火鸡淋巴细胞增生性疾病由C型逆转录病毒引起的分子证据。
J Virol. 1979 Sep;31(3):639-44. doi: 10.1128/JVI.31.3.639-644.1979.
10
Morphologic characterization of proliferative cells and virus particles in turkeys with lymphoproliferative disease.患有淋巴增生性疾病的火鸡中增殖细胞和病毒颗粒的形态学特征
J Natl Cancer Inst. 1979 Jun;62(6):1483-7.