Liu Haiyan
From the Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania.
Arch Pathol Lab Med. 2014 Dec;138(12):1629-42. doi: 10.5858/arpa.2014-0094-RA.
Immunohistochemistry is a valuable tool in routine breast pathology, used for both diagnostic and prognostic parameters. The diagnostic immunomarkers are the scope of this review. Most breast lesions can be diagnosed on routine hematoxylin-eosin sections; however, in several scenarios, such as morphologically equivocal cases or metastatic tumors of unknown primary, the appropriate application of immunohistochemistry adds true value in reaching an accurate diagnosis.
To evaluate the diagnostic utility of the most commonly studied immunomarkers in the field of breast pathology by review of the literature, using the database of indexed articles in PubMed (US National Library of Medicine, Bethesda, Maryland) from 1976 to 2013.
Literature review, and author's research data and personal practice experience.
The appropriate use of immunohistochemistry by applying a panel of immunomarkers and using a standardized technical and interpretational method will complement the morphologic assessment and aid in the accurate classification of difficult breast lesions and the identification of metastasis from a breast primary.
免疫组织化学是常规乳腺病理学中的一项重要工具，可用于诊断和预后评估。本综述的范围是诊断性免疫标志物。大多数乳腺病变可通过常规苏木精 - 伊红切片诊断；然而，在一些情况下，如形态学上模棱两可的病例或原发灶不明的转移性肿瘤，免疫组织化学的恰当应用对于准确诊断具有重要价值。
通过回顾1976年至2013年美国国立医学图书馆（位于马里兰州贝塞斯达）PubMed数据库中索引文章，评估乳腺病理学领域最常研究的免疫标志物的诊断效用。
文献综述、作者的研究数据及个人实践经验。
通过应用一组免疫标志物并采用标准化的技术和解释方法恰当使用免疫组织化学，将补充形态学评估，并有助于对疑难乳腺病变进行准确分类以及识别乳腺原发灶的转移。
