Liu Haiyan, Lin Fan
From the Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania.
Arch Pathol Lab Med. 2015 Jan;139(1):67-82. doi: 10.5858/arpa.2014-0056-RA.
Accurate classification of follicular-patterned thyroid lesions is not always an easy task on routine surgical hematoxylin-eosin-stained or cytologic fine-needle aspiration specimens. The diagnostic challenges are partially due to differential diagnostic criteria that are often subtle and subjective. In the past decades, tremendous advances have been made in molecular gene profiling of tumors and diagnostic immunohistochemistry, aiding in diagnostic accuracy and proper patient management.
To evaluate the diagnostic utility of the most commonly studied immunomarkers in the field of thyroid pathology by review of the literature, using the database of indexed articles in PubMed (US National Library of Medicine) from 1976-2013.
Literature review, authors' research data, and personal practice experience.
The appropriate use of immunohistochemistry by applying a panel of immunomarkers and using a standardized technical and interpretational method may complement the morphologic assessment and aid in the accurate classification of difficult thyroid lesions.
在常规手术苏木精 - 伊红染色或细针穿刺细胞学标本上，准确分类滤泡型甲状腺病变并非总是易事。诊断难题部分归因于鉴别诊断标准往往细微且主观。在过去几十年中，肿瘤分子基因谱分析和诊断性免疫组化取得了巨大进展，有助于提高诊断准确性和恰当的患者管理。
通过回顾文献，利用美国国立医学图书馆PubMed数据库中1976 - 2013年索引文章的数据库，评估甲状腺病理学领域最常研究的免疫标志物的诊断效用。
文献综述、作者的研究数据和个人实践经验。
通过应用一组免疫标志物并采用标准化的技术和解释方法来适当使用免疫组化，可能补充形态学评估并有助于准确分类疑难甲状腺病变。
