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从刚果民主共和国选择能裂解产 CTX-M-15 超广谱β-内酰胺酶的伤寒沙门氏菌血清型 Typhi 菌株的潜在治疗性噬菌体。

Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo.

机构信息

Eliava Institute of Bacteriophage, Microbiology & Virology and Tbilisi State University, Gotua Street 3, Tbilisi 0160, Georgia.

National Institute for Biomedical Research, University Teaching Hospital of Kinshasa, Kinshasa, Democratic Republic of the Congo.

出版信息

Viruses. 2018 Apr 3;10(4):172. doi: 10.3390/v10040172.

DOI:10.3390/v10040172
PMID:29614013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5923466/
Abstract

Recently, a Typhi isolate producing CTX-M-15 extended spectrum β-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of . Typhi, and in general.

摘要

最近，在刚果民主共和国分离到一株产 CTX-M-15 型超广谱β-内酰胺酶（ESBL）、对环丙沙星敏感性降低的伤寒沙门菌。我们筛选到对该分离株具有强烈裂解活性的噬菌体，这些噬菌体有可能用于伤寒沙门菌乃至 沙门菌属的基于噬菌体的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7bf/5923466/ed86724e3175/viruses-10-00172-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7bf/5923466/3adb920e4bc6/viruses-10-00172-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7bf/5923466/ed86724e3175/viruses-10-00172-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7bf/5923466/3adb920e4bc6/viruses-10-00172-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7bf/5923466/ed86724e3175/viruses-10-00172-g002.jpg

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