Represa A, Robain O, Tremblay E, Ben-Ari Y
INSERM U29, Paris, France.
Neurosci Lett. 1989 May 8;99(3):351-5. doi: 10.1016/0304-3940(89)90472-2.
Quantitative autoradiography was used to study changes in high affinity (Kd = 12 nM) binding sites for kainic acid, a marker of mossy fibers, in the hippocampus of childhood epileptics. We found a highly significant increase in the density of kainate binding sites in the CA3 region and in the fascia dentata in childhood epileptics as compared to age matched controls. We suggest that anatomical plasticity occurs in the hippocampus of human epileptics as in experimental models of epilepsy. The increase in kainate binding sites may contribute to the development of epileptic seizures.
采用定量放射自显影术研究了儿童癫痫患者海马中苔藓纤维标志物——红藻氨酸高亲和力（解离常数Kd = 12 nM）结合位点的变化。我们发现，与年龄匹配的对照组相比，儿童癫痫患者CA3区和齿状回中红藻氨酸结合位点的密度显著增加。我们认为，人类癫痫患者海马中存在解剖学可塑性，就如同癫痫实验模型一样。红藻氨酸结合位点的增加可能有助于癫痫发作的发展。
