Chen Zhenhong, Fang Haihong, Wang Li, Sun Fengjun, Wang Yong, Yin Zhe, Yang Huiying, Yang Wenhui, Wang Jie, Xia Peiyuan, Zhou Dongsheng, Liu Changting
Nanlou Respiratory Diseases Department, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
Sci Rep. 2014 Nov 27;4:7212. doi: 10.1038/srep07212.
Achromobacter xylosoxidans strain A22732 is isolated from a pneumonia patient in China and produces carbapenemases OXA-114e and IMP-1, which are encoded by chromosome and plasmid, respectively, and confer resistance to multiple ß-lactam antibiotics including carbapenems. The blaIMP-1 gene together with aacA7 and orfE is captured by a novel Tn402-like class 1 integron in a conjugative IncP-1ß plasmid. In addition to the intrinsic integron promoter PcW, there is still a blaIMP-1 gene cassette-specific promoter. This is the first report of carbapenemase-encoding IncP-1ß plasmid in clinical bacterial isolate.
木糖氧化无色杆菌菌株A22732从中国一名肺炎患者体内分离得到，可产生碳青霉烯酶OXA - 114e和IMP - 1，它们分别由染色体和质粒编码，并对包括碳青霉烯类在内的多种β-内酰胺抗生素具有抗性。blaIMP - 1基因与aacA7和orfE一起被一个新型的Tn402样1类整合子捕获在一个接合性IncP - 1β质粒中。除了固有的整合子启动子PcW外，还有一个blaIMP - 1基因盒特异性启动子。这是临床细菌分离株中编码碳青霉烯酶的IncP - 1β质粒的首次报道。
