Dorsey Jay F, Sun Lova, Joh Daniel Y, Witztum Alon, Kao Gary D, Alonso-Basanta Michelle, Avery Stephen, Hahn Stephen M, Al Zaki Ajlan, Tsourkas Andrew
Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Transl Cancer Res. 2013 Aug 1;2(4):280-291. doi: 10.3978/j.issn.2218-676X.2013.08.09.
The potential of gold nanoparticles (GNPs) in therapeutic and diagnostic cancer applications is becoming increasingly recognized. These biologically compatible particles can be easily synthesized, tuned to different sizes, and functionalized by conjugation to various biologically useful materials. Efficient and specific delivery to tumor tissue can then be accomplished either by passive accumulation in leaky tumor vessels and tissue, or by directly targeting tumor-specific biomarkers. Tumor-localized GNPs can serve as both adjuvants for enhancing the efficacy of radiation therapy and also as contrast agents for various imaging modalities. In this review, we will discuss recent advancements and future potential in the application of GNP as both a radiosensitizer and an imaging contrast agent. Due to their versatility and biocompatibility, gold nanoparticles may represent a novel theranostic adjuvant for radiation applications in cancer management.
金纳米颗粒（GNPs）在癌症治疗和诊断应用中的潜力正日益得到认可。这些具有生物相容性的颗粒易于合成，可调整至不同尺寸，并通过与各种生物有用材料共轭进行功能化。然后，通过在渗漏的肿瘤血管和组织中被动积累，或直接靶向肿瘤特异性生物标志物，可实现向肿瘤组织的高效且特异性递送。肿瘤局部的GNPs既可以作为增强放射治疗疗效的佐剂，也可以作为各种成像模态的造影剂。在本综述中，我们将讨论金纳米颗粒作为放射增敏剂和成像造影剂应用的最新进展及未来潜力。由于其多功能性和生物相容性，金纳米颗粒可能代表了一种用于癌症治疗中放射应用的新型治疗诊断佐剂。
