Tolosa Josefa, Font Guillermina, Mañes Jordi, Ferrer Emilia
Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia , Avenue Vicent Andrés Estellés s/n, 46100 Burjassot, Spain.
J Agric Food Chem. 2014 Dec 24;62(51):12462-70. doi: 10.1021/jf5036838. Epub 2014 Dec 10.
A new analytical method for the simultaneous determination of enniatins (ENs) and beauvericin (BEA) in fish feed and fish tissues by liquid chromatography coupled to mass spectrometry with linear ion trap (LC-MS/MS-LIT) was developed. Results showed that the developed method is precise and sensitive. The presence of emerging Fusarium mycotoxins, ENs and BEA, was determined in samples of aquaculture fish and feed for farmed fish, showing that all feed samples analyzed were contaminated with mycotoxins, with 100% coexistence. In aquacultured fish samples, the highest incidence was found in edible muscle and liver. As for the exposure assessment calculated, it was found that average consumer intake was lower than tolerable daily intake (TDI) values for other Fusarium mycotoxins.
建立了一种通过液相色谱-线性离子阱质谱联用（LC-MS/MS-LIT）同时测定鱼饲料和鱼组织中恩镰孢菌素（ENs）和白僵菌素（BEA）的新分析方法。结果表明，所建立的方法精确且灵敏。在养殖鱼类的水产养殖鱼和饲料样本中检测到了新出现的镰刀菌霉菌毒素ENs和BEA，表明所有分析的饲料样本均被霉菌毒素污染，且共存率为100%。在水产养殖鱼样本中，可食用肌肉和肝脏中的发生率最高。至于计算得出的暴露评估结果，发现普通消费者的摄入量低于其他镰刀菌霉菌毒素的每日耐受摄入量（TDI）值。
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