De Miguel Carmen, Rudemiller Nathan P, Abais Justine M, Mattson David L
Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Curr Hypertens Rep. 2015 Jan;17(1):507. doi: 10.1007/s11906-014-0507-z.
Research studying the role of inflammation in hypertension and cardiovascular disease has flourished in recent years; however, the exact mechanisms by which the activated immune cells lead to the development and maintenance of hypertension remain to be elucidated. The objectives of this brief review are to summarize and discuss the most recent findings in the field, with special emphasis on potential therapeutics to treat or prevent hypertension. This review will cover novel immune cell subtypes recently associated to the disease including the novel role of cytokines, toll-like receptors, and inflammasomes in hypertension.
近年来,关于炎症在高血压和心血管疾病中作用的研究蓬勃发展;然而,活化的免疫细胞导致高血压发生和维持的确切机制仍有待阐明。本简要综述的目的是总结和讨论该领域的最新发现,特别强调治疗或预防高血压的潜在疗法。本综述将涵盖最近与该疾病相关的新型免疫细胞亚型,包括细胞因子、Toll样受体和炎性小体在高血压中的新作用。