Ley Jessica, Wildes Tanya, El-Mofty Samir, Adkins Douglas
Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
Division of Surgical Pathology, Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA.
Ecancermedicalscience. 2014 Nov 13;8:480. doi: 10.3332/ecancer.2014.480. eCollection 2014.
Human papilloma virus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is associated with a favourable prognosis, although approximately 20-25% of patients ultimately develop recurrent cancer. Most disease recurrence events appear within 3 years; however, long-term follow-up of reported studies are limited, and the risk of late recurrence is unknown. We present a case report of a patient who developed distant metastases of HPV-related SCC 11 years after initial diagnosis and treatment of HPV-related OPSCC. Late disease recurrence may occur after initial diagnosis of HPV-related OPSCC. This observation has implications on the appropriate duration of follow-up and surveillance of these patients.
人乳头瘤病毒（HPV）相关的口咽鳞状细胞癌（OPSCC）预后良好，尽管约20%-25%的患者最终会发生癌症复发。大多数疾病复发事件发生在3年内；然而，已报道研究的长期随访有限，晚期复发风险未知。我们报告一例患者，在初次诊断和治疗HPV相关的OPSCC 11年后发生了HPV相关鳞状细胞癌的远处转移。HPV相关OPSCC初次诊断后可能发生晚期疾病复发。这一观察结果对这些患者的适当随访和监测时长具有启示意义。
