Düe W, Herbst W D, Loy V, Stein H
Institute of Pathology, Klinikum Steglitz, Free University of Berlin, West Germany.
J Clin Pathol. 1989 May;42(5):470-6. doi: 10.1136/jcp.42.5.470.
An adenoid cystic carcinoma of the breast in a 78 year old woman was analysed immunohistologically for the production of type IV collagen, the expression of vimentin, epithelial membrane antigen (EMA) and steroid receptors, and the proliferative activity of the tumour cells. The data were compared with those obtained in eight adenoid cystic carcinomas of salivary glands and in ductal carcinomas of the breast with a cribriform growth pattern. The patients' ages were as follows: 45-80 years (mean 63.2) for the salivary gland carcinomas; 37-69 years (mean 50.6) for the ductal breast carcinomas. In contrast to the cribriform spaces of ductal carcinomas, the pseudocysts in adenoid cystic carcinomas were lined by type IV collagen. The opposite pattern was observed for EMA. Like the myoepithelium of normal breast, the myoepithelium-like cells of adenoid cystic carcinoma stained positive for vimentin while the ductular epithelium-like ones did not. All adenoid cystic carcinomas, including that of the breast, were negative for the oestrogen and progesterone receptors, unlike the ductal carcinomas. Proliferative activity of the adenoid cystic carcinoma of the breast was relatively low. These data broaden the range of antibodies suitable for differential diagnosis of both tumour types. They may explain the differences in prognosis, and they explain why hormonal treatment or radiotherapy of adenoid cystic carcinoma of the breast are often ineffectual.
对一名78岁女性的乳腺腺样囊性癌进行了免疫组织学分析，以检测IV型胶原的产生、波形蛋白、上皮膜抗原（EMA）和类固醇受体的表达，以及肿瘤细胞的增殖活性。将这些数据与在8例唾液腺腺样囊性癌和具有筛状生长模式的乳腺导管癌中获得的数据进行比较。唾液腺癌患者的年龄如下：45 - 80岁（平均63.2岁）；乳腺导管癌患者的年龄为37 - 69岁（平均50.6岁）。与导管癌的筛状间隙不同，腺样囊性癌中的假囊肿内衬IV型胶原。EMA的情况则相反。与正常乳腺的肌上皮一样，腺样囊性癌的肌上皮样细胞波形蛋白染色呈阳性，而导管样上皮细胞则否。与导管癌不同，所有腺样囊性癌，包括乳腺腺样囊性癌，雌激素和孕激素受体均为阴性。乳腺腺样囊性癌的增殖活性相对较低。这些数据拓宽了适用于这两种肿瘤类型鉴别诊断的抗体范围。它们可能解释了预后的差异，也解释了为什么乳腺腺样囊性癌的激素治疗或放射治疗往往无效。
