Nieto M C, Tellería O, Cisterna R
Clinical Microbiology and Infection Control Department, Basurto University Hospital, Avda. Montevideo 18, 48013, Bilbao, Spain.
Clinical Microbiology and Infection Control Department, Basurto University Hospital, Avda. Montevideo 18, 48013, Bilbao, Spain.
Diagn Microbiol Infect Dis. 2015 Jan;81(1):34-40. doi: 10.1016/j.diagmicrobio.2014.05.021. Epub 2014 Jun 5.
In order to know the epidemiology and the changes of antifungal resistance in invasive candidiasis (IC) we carried out this prospective study of Candida strains belonging to patients admitted to 26 Spanish hospitals from June 2011 to June 2012 diagnosed with IC. Clinical information and the identity of the Candida species were collected and antifungal susceptibility was tested using broth microdilution in five agents: amphotericin B, fluconazole, voriconazole, caspofungin and anidulafungin. A total of 705 cases-isolates were documented. Most of the patients suffered from candidemia and several underlying diseases and more than half of them were neutropenic or under immunosuppressive therapy, factors associated with higher mortality. Thirty percent of global mortality was documented. C. albicans was the most frequently isolated species, although an increase of non-C. albicans species was observed. Resistance to fluconazole was of 3.4%, lower than in previous years (6.3%). C. parapsilosis presented a higher MIC90 of echinocandins compared to other species.
为了解侵袭性念珠菌病（IC）的流行病学及抗真菌药物耐药性变化，我们对2011年6月至2012年6月入住西班牙26家医院、被诊断为IC的患者所分离出的念珠菌菌株进行了这项前瞻性研究。收集了临床信息和念珠菌种类，并用肉汤微量稀释法对两性霉素B、氟康唑、伏立康唑、卡泊芬净和阿尼芬净这五种药物进行了抗真菌药敏试验。共记录了705例病例-菌株。大多数患者患有念珠菌血症及多种基础疾病，其中一半以上为中性粒细胞减少或接受免疫抑制治疗，这些因素与较高的死亡率相关。记录的总体死亡率为30%。白色念珠菌是最常分离出的菌种，不过非白色念珠菌的菌种有所增加。对氟康唑的耐药率为3.4%，低于前几年（6.3%）。近平滑念珠菌对棘白菌素的MIC90高于其他菌种。
