Vignon E, Mathieu P, Couprie N, Cloppet H, Herbage D, Louisot P, Richard M
Laboratoire d'Exploration Articulaire, Hopital Edouard Herriot, Lyon, France.
Semin Arthritis Rheum. 1989 Feb;18(3 Suppl 1):11-5. doi: 10.1016/0049-0172(89)90078-4.
IL-1 and prostaglandin (PGE2, PGF2 alpha, TXB2) concentrations, PLA2 activity, neutral protease activity, and collagenase activity specific for types I and II collagen were determined in the SF of patients suffering from RA, before and after treatment with TA. Active and latent forms of protease and collagenases were regularly detected but were unrelated to IL-1, PLA2, and PGE2. TA induced a significant decrease in tested eicosanoids but IL-1, PLA2, and proteases were unchanged.
在类风湿关节炎（RA）患者接受他克莫司（TA）治疗前后，测定其滑液（SF）中白细胞介素-1（IL-1）和前列腺素（前列腺素E2、前列腺素F2α、血栓素B2）浓度、磷脂酶A2（PLA2）活性、中性蛋白酶活性以及Ⅰ型和Ⅱ型胶原特异性胶原酶活性。蛋白酶和胶原酶的活性形式和潜在形式均被定期检测到，但与IL-1、PLA2和前列腺素E2无关。TA使所检测的类花生酸显著减少，但IL-1、PLA2和蛋白酶未发生变化。
