Fitzgerald Paul B, McQueen Susan, Daskalakis Zafiris J, Hoy Kate E
Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, Victoria 3004, Australia.
Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, Victoria 3004, Australia.
Brain Stimul. 2014 Nov-Dec;7(6):813-6. doi: 10.1016/j.brs.2014.08.002. Epub 2014 Aug 12.
A small number of studies conducted to date have suggested that transcranial direct current stimulation (tDCS) applied to the temporoparietal cortex may reduce auditory hallucinations in patients with schizophrenia. Prefrontal brain stimulation with other methods, has also been shown to potentially improve the negative symptoms of this disorder.
To investigate the therapeutic potential of daily bimodal tDCS: anodal stimulation to the prefrontal cortex and cathodal stimulation to the temporoparietal junction in patients with persistent hallucinations and negative symptoms of schizophrenia.
We conducted two small randomized double-blind controlled trials comparing bimodal tDCS to sham stimulation. In one study, stimulation was provided unilaterally, in the second study it was provided bilaterally.
Neither unilateral nor bilateral tDCS resulted in a substantial change in either hallucinations or negative symptoms. Stimulation was well tolerated without side-effects.
Daily tDCS does not appear to have substantial potential in the treatment of hallucinations or negative symptoms and further research should investigate higher doses of stimulation or more frequently applied treatment schedules.
迄今为止进行的少数研究表明，对颞顶叶皮质施加经颅直流电刺激（tDCS）可能会减少精神分裂症患者的幻听。使用其他方法对前额叶进行脑刺激，也已显示出有可能改善该疾病的阴性症状。
探讨每日进行双模式tDCS（对前额叶皮质进行阳极刺激，对颞顶叶交界处进行阴极刺激）对患有持续性幻觉和精神分裂症阴性症状患者的治疗潜力。
我们进行了两项小型随机双盲对照试验，将双模式tDCS与假刺激进行比较。在一项研究中，刺激单侧进行，在第二项研究中，刺激双侧进行。
单侧或双侧tDCS均未导致幻觉或阴性症状出现实质性变化。刺激耐受性良好，无副作用。
每日tDCS在治疗幻觉或阴性症状方面似乎没有很大潜力，进一步的研究应调查更高剂量的刺激或更频繁的治疗方案。
