MRC Centre for Neuropsychiatric Genetics and Genomics, and the Neuroscience and Mental Health Research Institute, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK.
Neuron. 2014 Nov 5;84(3):564-71. doi: 10.1016/j.neuron.2014.10.028.
Recent findings in psychiatric genetics have crystallized concerns that diagnostic categories used in the clinic map poorly onto the underlying biology. If we are to harness developments in genetics and neuroscience to understand disease mechanisms and develop new treatments, we need new approaches to patient stratification that recognize the complexity and continuous nature of psychiatric traits and that are not constrained by current categorical approaches. Recognizing this, the National Institute for Mental Health (NIMH) has developed a novel framework to encourage more research of this kind. The implications of these recent findings and funding policy developments for neuroscience research are considerable.
最近在精神遗传学方面的发现使人们更加关注临床中使用的诊断类别与潜在生物学之间的不匹配问题。如果我们要利用遗传学和神经科学的发展来了解疾病机制并开发新的治疗方法，我们需要采用新的方法对患者进行分层，这种方法要能够认识到精神特征的复杂性和连续性，并且不受当前分类方法的限制。有鉴于此，美国国立精神卫生研究所（NIMH）制定了一个新的框架，以鼓励开展更多此类研究。这些最新发现和资助政策的发展对神经科学研究具有重要意义。
