Traesel Giseli Karenina, de Souza Juliane Coelho, de Barros Aline Lima, Souza Marcos Alexandre, Schmitz Wanderley Onofre, Muzzi Rozanna Marques, Oesterreich Silvia Aparecida, Arena Arielle Cristina
School of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Food Chem Toxicol. 2014 Dec;74:320-25. doi: 10.1016/j.fct.2014.10.026.
Acrocomia aculeata, popularly known as “bocaiúva”, is a species used for nutritional purposes and for the treatment of various diseases, as it has, among other things, high levels of antioxidant compounds. This study aimed to assess the toxicological profile of A. aculeata, through acute and subacute toxicity tests. Male and female rats (Wistar) received by gavage 2000 mg/kg of oil extracted from the pulp of A. aculeata (OPAC) for the acute toxicity test and 125, 250, 500 or 1000 mg/kg of OPAC for subacute toxicity test. In the acute toxicity study no mortality or behavioral changes were observed in rats treated with 2000 mg/kg, indicating that the LD50 is higher than this dose. In the subacute toxicity test, the tested doses produced no significant changes in hematological, biochemical or histopathological parameters in the animals exposed. These results demonstrate the absence of acute and subacute toxicity after oral exposure to A. aculeata oil in rats. However, further studies in animals and in humans are needed in order to have sufficient safety evidence for its use in humans.
刺葵，俗称“博卡尤瓦”，是一种用于营养目的和治疗各种疾病的物种，因为它除其他外含有高水平的抗氧化化合物。本研究旨在通过急性和亚急性毒性试验评估刺葵的毒理学特征。雄性和雌性大鼠（Wistar）在急性毒性试验中通过灌胃给予2000mg/kg从刺葵果肉中提取的油（OPAC），在亚急性毒性试验中给予125、250、500或1000mg/kg的OPAC。在急性毒性研究中，接受2000mg/kg处理的大鼠未观察到死亡或行为变化，表明半数致死量高于此剂量。在亚急性毒性试验中，受试剂量在暴露动物的血液学、生化或组织病理学参数上未产生显著变化。这些结果表明大鼠口服刺葵油后不存在急性和亚急性毒性。然而，为了有足够的安全证据证明其在人类中的使用，还需要在动物和人类中进行进一步研究。
