Antidiabetic, cytotoxic and antioxidant activities of oil extracted from pulp.

This study evaluated the hypoglycemic effect of the oil extracted from the pulp (OPAC) in normoglycemic rats and streptozotocin (STZ), fructose-induced diabetic rat models and its antioxidant and cytotoxic potential. OPAC (3, 30 300 mg/kg, v.o.) significantly decreased ( < 0.05) the high glucose levels induced by a high fructose-diet in rats. Persistent treatment with OPAC for 24 days also reduced the high plasmatic glucose induced by STZ. In normoglycemic animals, OPAC significantly decreased glucose levels. While oil exhibited good antioxidant activity, no sign of cytotoxicity was observed in LLC-PK1 cells (5-500 μg/mL). OPAC has antidiabetic and antioxidant activities without causing cytotoxicity.