a Federal University of Grande Dourados , Dourados , Brazil.
b Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
Nat Prod Res. 2019 Aug;33(16):2413-2416. doi: 10.1080/14786419.2018.1446006. Epub 2018 Feb 28.
This study evaluated the hypoglycemic effect of the oil extracted from the pulp (OPAC) in normoglycemic rats and streptozotocin (STZ), fructose-induced diabetic rat models and its antioxidant and cytotoxic potential. OPAC (3, 30 300 mg/kg, v.o.) significantly decreased ( < 0.05) the high glucose levels induced by a high fructose-diet in rats. Persistent treatment with OPAC for 24 days also reduced the high plasmatic glucose induced by STZ. In normoglycemic animals, OPAC significantly decreased glucose levels. While oil exhibited good antioxidant activity, no sign of cytotoxicity was observed in LLC-PK1 cells (5-500 μg/mL). OPAC has antidiabetic and antioxidant activities without causing cytotoxicity.
本研究评估了从果肉中提取的油（OPAC）在正常血糖大鼠和链脲佐菌素（STZ）、果糖诱导的糖尿病大鼠模型中的降血糖作用及其抗氧化和细胞毒性潜力。OPAC（3、30 和 300 mg/kg，口服）可显著降低（<0.05）高果糖饮食诱导的大鼠高血糖水平。持续 24 天用 OPAC 治疗也可降低 STZ 诱导的高血浆葡萄糖水平。在正常血糖动物中，OPAC 可显著降低血糖水平。虽然油表现出良好的抗氧化活性，但在 LLC-PK1 细胞（5-500μg/mL）中未观察到细胞毒性迹象。OPAC 具有抗糖尿病和抗氧化活性，不会引起细胞毒性。
