Cayuso Jordi, Xu Qiling, Wilkinson David G
Division of Developmental Neurobiology, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom.
Division of Developmental Neurobiology, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom.
Dev Biol. 2015 May 1;401(1):122-31. doi: 10.1016/j.ydbio.2014.11.013. Epub 2014 Nov 20.
The formation of sharp borders, across which cell intermingling is restricted, has a crucial role in the establishment and maintenance of organized tissues. Signaling of Eph receptors and ephrins underlies formation of a number of boundaries between and within tissues during vertebrate development. Eph-ephrin signaling can regulate several types of cell response-adhesion, repulsion and tension-that can in principle underlie the segregation of cells and formation of sharp borders. Recent studies have implicated each of these cell responses as having important roles at different boundaries: repulsion at the mesoderm-ectoderm border, decreased adhesion at the notochord-presomitic mesoderm border, and tension at boundaries within the hindbrain and forebrain. These distinct responses to Eph receptor and ephrin activation may in part be due to the adhesive properties of the tissue.
形成限制细胞相互混合的清晰边界，在有组织的组织的建立和维持中起着关键作用。在脊椎动物发育过程中，Eph受体和ephrin的信号传导是组织之间和组织内部许多边界形成的基础。Eph-ephrin信号传导可以调节几种类型的细胞反应——粘附、排斥和张力——原则上这些反应可以作为细胞分离和清晰边界形成的基础。最近的研究表明，这些细胞反应中的每一种在不同边界都起着重要作用：中胚层-外胚层边界处的排斥，脊索-前体节中胚层边界处粘附力的降低，以及后脑和前脑内部边界处的张力。对Eph受体和ephrin激活的这些不同反应可能部分归因于组织的粘附特性。
