Niethamer Terren K, Bush Jeffrey O
Department of Cell and Tissue Biology, Program in Craniofacial Biology, and Institute of Human Genetics, University of California at San Francisco, San Francisco, CA 94143, USA.
Department of Cell and Tissue Biology, Program in Craniofacial Biology, and Institute of Human Genetics, University of California at San Francisco, San Francisco, CA 94143, USA.
Dev Biol. 2019 Mar 1;447(1):42-57. doi: 10.1016/j.ydbio.2018.01.012. Epub 2018 Jan 31.
In vertebrates, the Eph/ephrin family of signaling molecules is a large group of membrane-bound proteins that signal through a myriad of mechanisms and effectors to play diverse roles in almost every tissue and organ system. Though Eph/ephrin signaling has functions in diverse biological processes, one core developmental function is in the regulation of cell position and tissue morphology by regulating cell migration and guidance, cell segregation, and boundary formation. Often, the role of Eph/ephrin signaling is to translate patterning information into physical movement of cells and changes in morphology that define tissue and organ systems. In this review, we focus on recent advances in the regulation of these processes, and our evolving understanding of the in vivo signaling mechanisms utilized in distinct developmental contexts.
在脊椎动物中，Eph/ephrin信号分子家族是一大类膜结合蛋白，它们通过无数种机制和效应器发出信号，在几乎每个组织和器官系统中发挥着多样的作用。尽管Eph/ephrin信号传导在多种生物学过程中发挥作用，但其一个核心的发育功能是通过调节细胞迁移和导向、细胞分离以及边界形成来调控细胞位置和组织形态。通常，Eph/ephrin信号传导的作用是将模式信息转化为细胞的物理运动以及形态变化，这些变化定义了组织和器官系统。在这篇综述中，我们重点关注这些过程调控方面的最新进展，以及我们对在不同发育背景下所利用的体内信号传导机制的不断深入理解。
