Witt Whitney P, Mandell Kara C, Wisk Lauren E, Cheng Erika R, Chatterjee Debanjana, Wakeel Fathima, Park Hyojun, Zarak Dakota
Maternal and Child Health Research, Truven Health Analytics, 4819 Emperor Boulevard, Suite 125, Durham, NC, 27703, USA,
Arch Womens Ment Health. 2015 Jun;18(3):523-37. doi: 10.1007/s00737-014-0477-9. Epub 2014 Dec 2.
The purpose of the study was to understand the association between stressful life events prior to conception (PSLEs) and women's alcohol and tobacco use prior to and during pregnancy, and the continuation of such use through pregnancy. Data were from the Early Childhood Longitudinal Study-Birth Cohort (n = 9,350). Data were collected in 2001. Exposure to PSLEs was defined by indications of death of a parent, spouse, or previous live born child, divorce or marital separation, or fertility problems prior to conception. Survey data determined alcohol and tobacco usage during the 3 months prior to and in the final 3 months of pregnancy. Weighted regressions estimated the effect of PSLEs on alcohol and tobacco use at each time point and on the continuation of use, adjusting for confounders. Experiencing any PSLE increased the odds of tobacco use prior to (adjusted odds ratio [AOR] 1.52, 95 % confidence interval (CI) 1.23-1.87) and during pregnancy (AOR 1.57, 95 % CI 1.19-2.07). Women exposed to PSLEs smoked nearly five additional packs of cigarettes in the 3 months prior to pregnancy (97 cigarettes, p = 0.011) and consumed 0.31 additional alcoholic drinks during the last 3 months of pregnancy than unexposed women. PSLEs are associated with tobacco use before pregnancy and alcohol and tobacco use during pregnancy. Alcohol and tobacco screening and cessation services should be implemented prior to and during pregnancy, especially for women who have experienced PSLEs.
该研究的目的是了解受孕前的应激性生活事件(PSLEs)与女性怀孕前及怀孕期间的烟酒使用情况,以及此类使用在孕期的持续情况之间的关联。数据来自儿童早期纵向研究——出生队列(n = 9350)。数据于2001年收集。PSLEs的暴露定义为受孕前父母、配偶或之前存活的孩子死亡、离婚或婚姻分居、或生育问题的迹象。调查数据确定了怀孕前3个月及怀孕最后3个月期间的烟酒使用情况。加权回归估计了PSLEs在每个时间点对烟酒使用及使用持续情况的影响,并对混杂因素进行了调整。经历任何PSLE都会增加怀孕前(调整后的优势比[AOR] 1.52,95%置信区间[CI] 1.23 - 1.87)及怀孕期间吸烟的几率(AOR 1.57,95% CI 1.19 - 2.07)。暴露于PSLEs的女性在怀孕前3个月比未暴露的女性多吸近五包香烟(97支,p = 0.011),在怀孕最后3个月多饮用0.31杯酒精饮料。PSLEs与怀孕前的吸烟以及怀孕期间的烟酒使用有关。应在怀孕前及怀孕期间提供烟酒筛查和戒烟服务,尤其是对于经历过PSLEs的女性。