根据运动障碍学会（MDS）工作组标准诊断帕金森病轻度认知障碍（PD-MCI）：需要多少项以及哪些神经心理学测试？
Diagnosing PD-MCI by MDS Task Force criteria: how many and which neuropsychological tests?
作者信息
Goldman Jennifer G, Holden Samantha, Ouyang Bichun, Bernard Bryan, Goetz Christopher G, Stebbins Glenn T
机构信息
Rush University Medical Center, Department of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Chicago, IL, USA.
出版信息
Mov Disord. 2015 Mar;30(3):402-6. doi: 10.1002/mds.26084. Epub 2014 Dec 1.
Abstract
BACKGROUND
The optimal properties of a comprehensive (level II) neuropsychological battery for determining Parkinson's disease mild cognitive impairment (PD-MCI) by Movement Disorder Society (MDS) Task Force criteria remain unresolved.
METHODS
Seventy-six nondemented PD patients underwent PD-MCI classification using a consensus diagnosis and level II criteria. We examined the optimal number of tests in each of the five designated cognitive domains, identified the best tests within each domain, and determined the best overall battery for PD-MCI level II diagnosis.
RESULTS
A battery with two tests per domain provided a highly practical, robust diagnostic assessment. Level II testing with the two best tests and impairment defined as 2 standard deviations below norms was highly sensitive and specific for PD-MCI diagnosis.
CONCLUSIONS
Our findings strongly support the MDS Task Force Level II testing recommendations, provide a framework for creating an optimal, efficient neuropsychological test battery for PD-MCI diagnosis, and offer specific test recommendations.
摘要
背景
依据运动障碍协会（MDS）特别工作组标准，用于判定帕金森病轻度认知障碍（PD-MCI）的综合性（二级）神经心理成套测验的最佳属性仍未明确。
方法
76名无痴呆的帕金森病患者依据共识诊断和二级标准进行了PD-MCI分类。我们检查了五个指定认知领域中每个领域的最佳测试数量，确定了每个领域内的最佳测试，并确定了用于PD-MCI二级诊断的最佳整体成套测验。
结果
每个领域两项测试的成套测验提供了高度实用、可靠的诊断评估。使用两项最佳测试进行二级测试，并将损伤定义为低于常模2个标准差，对PD-MCI诊断具有高度敏感性和特异性。
结论
我们的研究结果有力支持了MDS特别工作组的二级测试建议，为创建用于PD-MCI诊断的最佳、高效神经心理测试成套测验提供了框架，并提供了具体的测试建议。
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