Cheng Chia-Hsiung, Baillet Sylvain, Hsiao Fu-Jung, Lin Yung-Yang
Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; Laboratory of Neurophysiology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada.
McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada.
Biol Psychol. 2015 Jan;104:48-55. doi: 10.1016/j.biopsycho.2014.11.003. Epub 2014 Nov 15.
The ability to discriminate speech sounds is crucial for higher language functions in humans. However, it remains unclear whether physiological aging affects the functional integrity of pre-attentive phonological discrimination. The neuromagnetic cortical responses during automatic change detection of speech sounds (/ba/versus/da/) were recorded in 24 young and 21 aged male adults. We used minimum norm estimate of source reconstruction to characterize the spatiotemporal dynamics of magnetic mismatch responses (MMNm). Distributed activations to phonetic changes were identified in the temporal, frontal and parietal regions. Compared to younger participants, elderly volunteers exhibited a significant reduction of cortical responses to phonetic-MMNm, except for the left orbitofrontal cortex and anterior inferior temporal gyrus. However, among the identified regions of interest, we did not observe significant between-group differences in the hemispheric asymmetry of phonetic-MMNm. Conclusively, our results suggest an altered phonetic processing at the perceptual level during physiological aging.
辨别语音的能力对人类的高级语言功能至关重要。然而，尚不清楚生理衰老是否会影响前注意音韵辨别功能的完整性。在24名年轻男性和21名老年男性成年人中记录了语音自动变化检测（/ba/与/da/）过程中的神经磁皮层反应。我们使用源重建的最小范数估计来表征磁失配反应（MMNm）的时空动态。在颞叶、额叶和顶叶区域发现了对语音变化的分布式激活。与年轻参与者相比，老年志愿者对语音MMNm的皮层反应显著降低，但左侧眶额皮质和颞下回前部除外。然而，在确定的感兴趣区域中，我们未观察到语音MMNm半球不对称性的显著组间差异。总之，我们的结果表明，在生理衰老过程中，感知水平的语音处理发生了改变。
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