书写痉挛患者体感网络功能连接性降低。
Reduced functional connectivity of somatosensory network in writer's cramp patients.
作者信息
Cheng Chia-Hsiung, Tseng Yi-Jhan, Chen Rou-Shayn, Lin Yung-Yang
机构信息
Department of Occupational Therapy Graduate Institute of Behavioral Sciences Chang Gung University Taoyuan Taiwan; Healthy Aging Research Center Chang Gung University Taoyuan Taiwan; Department of Psychiatry Chang Gung Memorial Hospital Taoyuan Taiwan.
Institute of Physiology National Yang-Ming University Taipei Taiwan; Laboratory of Neurophysiology Taipei Veterans General Hospital Taipei Taiwan.
出版信息
Brain Behav. 2016 Jan 26;6(3):e00433. doi: 10.1002/brb3.433. eCollection 2016 Mar.
BACKGROUND
The involvement of motor cortex and sensorimotor integration in patients with writer's cramp (WC) has been well documented. However, the exact neurophysiological profile within the somatosensory system, including primary somatosensory cortex (SI), contralateral (SIIc), and ipsilateral (SIIi) secondary somatosensory areas remains less understood.
METHODS
This study investigated the neuromagnetic cortical activities of median nerve stimulation in 10 patients with WC and 10 healthy controls (HC). To comprehensively explore all the aspects of somatosensory functioning, we analyzed our data with the minimum norm estimate (MNE), the time-frequency approach with evoked and induced activities, and functional connectivity between SI and SIIc (SI-SIIc), SI and SIIi (SI-SIIi), and SIIc and SIIi (SIIc-SIIi) from theta to gamma oscillations.
RESULTS
No significant between-group differences were found in the MNE cortical amplitudes of SI, SIIc, and SIIi. Power strengths of evoked gamma oscillation and induced beta synchronization were also equivalent between WC and HC groups. However, we found significantly reduced theta coherence of SI-SIIi, alpha coherence of SI-SIIi and SIIc-SIIi, as well as beta coherence of SIIc-SIIi in patients with WC.
CONCLUSION
Our results suggest the involvement of somatosensory abnormalities, primarily with the form of functional connectivity, in patients with WC.
背景
书写痉挛（WC）患者运动皮层和感觉运动整合的参与情况已有充分记录。然而，体感系统内确切的神经生理特征，包括初级体感皮层（SI）、对侧（SIIc）和同侧（SIIi）次级体感区域，仍了解较少。
方法
本研究调查了10例WC患者和10名健康对照者（HC）正中神经刺激的神经磁皮层活动。为全面探索体感功能的各个方面，我们采用最小范数估计（MNE）、具有诱发和诱导活动的时频方法以及从θ到γ振荡的SI与SIIc（SI-SIIc）、SI与SIIi（SI-SIIi）以及SIIc与SIIi（SIIc-SIIi）之间的功能连接来分析数据。
结果
SI、SIIc和SIIi的MNE皮层振幅在组间未发现显著差异。WC组和HC组诱发的γ振荡功率强度和诱导的β同步性也相当。然而，我们发现WC患者中SI-SIIi的θ相干性、SI-SIIi和SIIc-SIIi的α相干性以及SIIc-SIIi的β相干性显著降低。
结论
我们的结果表明WC患者存在体感异常，主要表现为功能连接形式。
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