Chen Haiyan, Zheng Shucong, Wang Yuankai, Zhu Huiqing, Liu Qiong, Xue Yu, Qiu Jianhua, Zou Hejian, Zhu Xiaoxia
Division of Rheumatology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040.
Institute of Rheumatology, Immunology and Allergy, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040.
Clin Rheumatol. 2016 May;35(5):1189-95. doi: 10.1007/s10067-014-2836-3. Epub 2014 Dec 3.
Gouty arthritis is characterized by inflammation induced by monosodium urate (MSU) crystal deposition, which is resulted by an increase of serum urate concentration. The management of gout, especially the recurrent acute attacks of chronic gouty arthritis, is still a problem to be resolved. In this study, we aimed to develop the preventive and therapeutic effect of resveratrol on gouty arthritis. MSU was used to induce gouty arthritis in the foot pad of C57BL/6 mice. Yeast polysaccharide and potassium oxonate were used to induce hyperuricemia in Kunming mice. Resveratrol was intraperitoneal injected to the mice in the treatment group. The pad inflammation and the level of serum uric acid were investigated to estimate the effect of resveratrol in gouty arthritis. Hyperuricemia was significantly detected in the mice treated with yeast polysaccharide and potassium oxonate, and gouty arthritis was successfully induced with MSU in mice. We further identified that resveratrol inhibited pad swelling and pad 99mTc uptake in gouty mice. Moreover, serum uric acid level was also decreased by resveratrol in hyperuricemia mice. This study highlighted that resveratrol might be applied to prevent the recurrent acute attack of gouty arthritis because of its inhibition of articular inflammation and down-regulation of serum uric acid.
痛风性关节炎的特征是由尿酸钠（MSU）晶体沉积诱导的炎症，这是由血清尿酸浓度升高所致。痛风的治疗，尤其是慢性痛风性关节炎的反复急性发作，仍然是一个有待解决的问题。在本研究中，我们旨在探讨白藜芦醇对痛风性关节炎的预防和治疗作用。采用MSU诱导C57BL/6小鼠足垫痛风性关节炎。采用酵母多糖和氧嗪酸钾诱导昆明小鼠高尿酸血症。治疗组小鼠腹腔注射白藜芦醇。通过观察足垫炎症和血清尿酸水平来评估白藜芦醇对痛风性关节炎的作用。在酵母多糖和氧嗪酸钾处理的小鼠中显著检测到高尿酸血症，并且成功地用MSU诱导了小鼠痛风性关节炎。我们进一步发现白藜芦醇抑制痛风小鼠的足垫肿胀和足垫99mTc摄取。此外，白藜芦醇还降低了高尿酸血症小鼠的血清尿酸水平。本研究强调，白藜芦醇可能因其对关节炎症的抑制作用和血清尿酸的下调作用而应用于预防痛风性关节炎的反复急性发作。
