从膳食补充剂到候选药物的白藜芦醇:潜力评估
Resveratrol from Dietary Supplement to a Drug Candidate: An Assessment of Potential.
作者信息
Khattar Shivani, Khan Sauban Ahmed, Zaidi Syed Amir Azam, Darvishikolour Mahdi, Farooq Uzma, Naseef Punnoth Poonkuzhi, Kurunian Mohamed Saheer, Khan Mohammed Zaafar, Shamim Athar, Khan Mohd Masih Uzzaman, Iqbal Zeenat, Mirza Mohd Aamir
机构信息
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
出版信息
Pharmaceuticals (Basel). 2022 Aug 1;15(8):957. doi: 10.3390/ph15080957.
Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements and botanical products. It shows a wide range of pharmacological/beneficial effects. Therefore, it can be a potential candidate to be developed as phyto-pharmaceutical. Multiple diseases are reported to be treated by the therapeutic effect of RVT since it has antioxidant, anti-cancer activity and anti-inflammatory activities. It also has a major role in diabetes, arthritis, cardiac disorder and platelet aggregation etc. The major requirements are establishments regarding safety, efficacy profile and physicochemical characterization. As it is already being consumed in variable maximum daily dose, there should not be a major safety concern but the dose needs to be established for different indications. Clinical trials are also being reported in different parts of the world. Physicochemical properties of the moiety are also well reported. Moreover, due to its beneficial effect on health it leads to the development of some intellectual property in the form of patents.
白藜芦醇(RVT)是一种广为人知的植物化学物质,广泛应用于膳食补充剂和植物产品中。它具有广泛的药理/有益作用。因此,它有可能被开发成为植物药。据报道,由于RVT具有抗氧化、抗癌和抗炎活性,多种疾病可通过其治疗作用得到治疗。它在糖尿病、关节炎、心脏疾病和血小板聚集等方面也发挥着重要作用。主要要求包括安全性、疗效概况和理化特性的确立。由于它已经以不同的最大日剂量被消费,因此不应存在重大安全问题,但需要为不同适应症确定剂量。世界各地也在报道相关的临床试验。该部分的理化性质也有充分报道。此外,由于其对健康的有益作用,它还催生了一些专利形式的知识产权。