Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, and ∥Research Institute of Oceanography, Seoul National University , NS-80, 151-747, Seoul, Republic of Korea.
J Nat Prod. 2014 Dec 26;77(12):2716-9. doi: 10.1021/np500558b. Epub 2014 Dec 2.
Intensive investigation of the chemical components of a Streptomyces sp. isolated from mudflat sediments collected on the southern coast of the Korean peninsula led to the isolation of three new compounds, anithiactins A-C (1-3). The chemical structures of anithiactins A and C were determined by interpretation of NMR data analyses, while the chemical structure of anithiactin B was established from a combination of NMR spectroscopic and crystallographic data analyses. The structure of anithiactin A was also confirmed by total synthesis. These three anithiactins displayed moderate acetylcholinesterase inhibitory activity with no significant cytotoxicity.
从朝鲜半岛南部沿海滩涂沉积物中分离得到的一株链霉菌进行了深入的化学成分研究，从中分离得到了三种新化合物，即 anithiactins A-C（1-3）。通过对 NMR 数据分析的解释，确定了 anithiactins A 和 C 的化学结构，而 anithiactin B 的化学结构则是通过 NMR 光谱和晶体学数据分析的组合确定的。anithiactin A 的结构也通过全合成得到了证实。这三种 anithiactins 表现出中等的乙酰胆碱酯酶抑制活性，且没有明显的细胞毒性。
