来自海洋来源的绿孢链霉菌的硫代孢菌素A-C、噻嗪和噻唑衍生物。
Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora.
作者信息
Fu Peng, MacMillan John B
机构信息
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States.
出版信息
J Nat Prod. 2015 Mar 27;78(3):548-51. doi: 10.1021/np500929z. Epub 2015 Jan 13.
Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 μM.
硫代孢菌素A（1）是首个含有5-羟基-4H-1,3-噻嗪-4-酮部分的天然产物，与两种新的噻唑衍生物硫代孢菌素B和C（2和3）一起，从海洋来源的绿产放线孢菌SNC-032中分离得到。通过综合光谱分析和化学方法确定了1-3的结构。硫代孢菌素A对非小细胞肺癌细胞系H2122显示出细胞毒性，IC50值为5.4 μM。
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