Winograd Nicholas
Department of Chemistry, Penn State University , University Park, Pennsylvania 16875, United States.
Anal Chem. 2015 Jan 6;87(1):328-33. doi: 10.1021/ac503650p. Epub 2014 Dec 17.
Imaging with cluster secondary ion mass spectrometry (SIMS) is reaching a mature level of development. Using a variety of molecular ion projectiles to stimulate desorption, 3-dimensional imaging with the selectivity of mass spectrometry can now be achieved with submicrometer spatial resolution and <10 nm depth resolution. In this Perspective, stock is taken regarding what it will require to routinely achieve these remarkable properties. Issues include the chemical nature of the projectile, topography formation, differential erosion rates, and perhaps most importantly, ionization efficiency. Shortcomings of existing instrumentation are also noted. Speculation about how to successfully resolve these issues is a key part of the discussion.
采用团簇二次离子质谱法（SIMS）进行成像正发展到成熟阶段。通过使用各种分子离子射弹来激发解吸，现在可以实现具有质谱选择性的三维成像，其空间分辨率可达亚微米级，深度分辨率小于10纳米。在这篇观点文章中，我们探讨了要常规实现这些卓越性能需要具备哪些条件。问题包括射弹的化学性质、形貌形成、差异侵蚀速率，或许最重要的是电离效率。文中还指出了现有仪器的不足之处。关于如何成功解决这些问题的推测是讨论的关键部分。
