Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, FL 32306, USA.
Department of Chemistry and Biochemistry, Florida State University, 95 Chieftain Way, Tallahassee, FL 32306, USA.
J Chromatogr A. 2015 Feb 20;1382:98-116. doi: 10.1016/j.chroma.2014.10.039. Epub 2014 Oct 23.
Microfluidic devices offer great advantages in integrating sample processes, minimizing sample and reagent volumes, and increasing analysis speed, while mass spectrometry detection provides high information content, is sensitive, and can be used in quantitative analyses. The coupling of microfluidic devices to mass spectrometers is becoming more common with the strengths of both systems being combined to analyze precious and complex samples. This review summarizes select achievements published between 2010 and July 2014 in novel coupling between microfluidic devices and mass spectrometers. The review is subdivided by the types of ionization sources employed, and the different microfluidic systems used.
微流控芯片在整合样品处理、最小化样品和试剂用量以及提高分析速度方面具有很大的优势，而质谱检测则提供了高信息量、高灵敏度，并可用于定量分析。将微流控芯片与质谱仪相结合变得越来越普遍，因为这两种系统的优势可以结合起来分析珍贵而复杂的样品。本综述总结了 2010 年至 2014 年 7 月期间在微流控芯片与质谱仪的新型耦合方面发表的部分成果。综述按所采用的电离源类型和不同的微流控系统进行了细分。
